A dual wedge microneedle for sampling of perilymph solution via round window membrane
نویسندگان
چکیده
منابع مشابه
Quantification of solute entry into cochlear perilymph through the round window membrane.
The administration of drugs to the inner ear via the round window membrane is becoming more widely used for both clinical and experimental purposes. The actual drug levels achieved in different regions of the inner ear by this method have not been established. The present study has made use of simulations of solute movements in the cochlear fluids to describe the distribution of a marker solute...
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متن کاملIsosorbide Concentration in Perilymph of the Guinea Pig After Oral Administration Versus That After Round Window Perfusion
OBJECTIVES The aims of this study were to investigate the feasibility of isosorbide delivery into perilymph through the round window membrane (RWM), and to compare the intracochlear isosorbide concentration in perilymph after oral administration (PO) versus that after round window perfusion (RWP). METHODS Sixteen male guinea pigs (32 ears) were used. Isosorbide, an osmotic diuretic, was admin...
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ژورنال
عنوان ژورنال: Biomedical Microdevices
سال: 2016
ISSN: 1387-2176,1572-8781
DOI: 10.1007/s10544-016-0046-2